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KMID : 1146920190490060603
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Journal of Pharmaceutical Investigation
2019 Volume.49 No. 6 p.603 ~ p.612
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Medicinal plants and phytochemicals for diabetes mellitus: pharmacokinetic characteristics and herb-drug interactions
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Han Dong-Gyun
Cho Seung-Sik
Kwak Jae-Hwan
Yoon In-Soo
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Abstract
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Background: Diabetes mellitus (diabetes) is a group of chronic metabolic diseases characterized by high blood sugar levels over a prolonged period, eventually leading to damage of multiple body systems. To date, drug-based therapies have not provided ideal clinical outcomes for effective and safe management of diabetes and its complications. Over the past decade, the use of complementary and alternative medicines (e.g., medicinal herbs and dietary supplements) for the management of chronic diseases such as diabetes has greatly increased around the world. However, herbal medicinal products are complex mixtures of various bioactive constituents that can modulate drug-metabolizing enzymes, particularly cytochrome P450 (CYP), and interact with prescription drugs through pharmacokinetic mechanisms.
Area covered: Thus, a summary on the effects of antidiabetic herbs and phytochemicals on the pharmacokinetics of antidiabetic drugs may prove relevant for optimizing antidiabetic therapy. The aim of this article is to provide an updated review of the pharmacokinetic characteristics of antidiabetic herbs and phytochemicals and their interactions with conventional antidiabetic drugs.
Expert opinion: Since herb-drug interactions may lead to substantial pharmacodynamic and/or pharmacokinetic consequences, further research in relevant fields of diabetes and herbal medicine is needed to continuously improve our knowledge of potential risks and benefits associated with these interactions.
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KEYWORD
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Diabetes, Herb-drug interaction, Phytochemical, Pharmacokinetics
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